Gherici Hassaine, our advisor and former CSO of Theranyx has built 100s of stable cell lines for antibody discovery in his 20+ years career.
Over a million receptors per cell. Gherici has developed cell lines that can be switched on (tetracycline-inducible) to begin receptor expression. This makes the cell lines less toxic, hence the higher receptor count.
With 5 years of development, we have reached high accuracy in our generative models, enabling for effective target-specific library designs.
Where most rely on generic libraries, we generate de-novo target-specific libraries and focus on functional epitopes.
In our lab, we screen our target-specific libraries against cells with high receptor counts to reach a high number of binders.
The panning outputs are then sent for deep sequencing and the results are analysed to capture diverse and cross-reactive sequences. Finally, we check the shortlisted antibodies for agonistic and antagonistic functions.
We work to make things better for everyone: both on a societal level and a personal level. We will thrive, as a team, as a company and as a society by combining intellect and thoughtfulness across everything we do.
We move fast and innovate in our thinking, yet combine this agility with utter rigour and robustness. We are dedicated to delivering reliable solutions.
An ugly word for a beautiful idea. Our interdisciplinary approach goes deeper than our science. We believe that the best ideas and the most interesting conversations come from synthesising diverse expertise and experiences.
We fundamentally believe in the value of each individual and the worth of their contribution, regardless of the outcome. We thrive best in a nurturing environment, and everything we do is committed to building a supportive culture.
We have the potential to transform lives. We will not let ourselves be sidetracked in this calling. We will not fail those whose future we can save.
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Co-founded in 2017, our team is dedicated to engineering the future of drug discovery to change the course of people’s lives. We are passionate about what we do and the impact our discoveries have on patients across the globe.
Based in Cardiff, our expert team spans structural biology, machine learning and medicine - and together, we are striving for that next breakthrough in drug discovery.
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