Engineering the future of
drug discovery
We use machine learning to design antibodies against difficult targets such as GPCRs and ion channels.
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WHAT WE DO
Engineering Functional Antibodies Targeting GPCRs in 6 Months
It is difficult to discover antibodies against GPCRs because of cells with low receptor count and antibody libraries with poor specificity.

At Antiverse, we built a discovery platform that develops cells with high receptor counts (1M per cell) and antibody libraries with high specificity against each target.

Cells with high receptor count

Gherici Hassaine, our Director of Antibody Discovery, has built 100s of stable cell lines for antibody discovery in his 20+ years career.

Over a million receptors per cell. Gherici has developed cell lines that can be switched on (tetracycline-inducible) to begin receptor expression. This makes the cell lines less toxic, hence the higher receptor count.

AI-generated  specific antibody libraries

With 5 years of development, we have reached high accuracy in our generative models, enabling for effective target-specific library designs.

Where most rely on generic libraries, we generate de-novo target-specific libraries and focus on functional epitopes.

Deep sequencing and AI-based clustering

In our lab, we screen our target-specific libraries against cells with high receptor counts to reach a high number of binders.

The panning outputs are then sent for deep sequencing and the results are analysed to capture diverse and cross-reactive sequences. Finally, we check the shortlisted antibodies for agonistic and antagonistic functions.

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WHO WE ARE
Our Values
  • 1

    People first

    We work to make things better for everyone: both on a societal level and a personal level. We will thrive, as a team, as a company and as a society by combining intellect and thoughtfulness across everything we do.

  • 2

    Rigour and Agility

    We move fast and innovate in our thinking, yet combine this agility with utter rigour and robustness. We are dedicated to delivering reliable solutions.

  • 3

    Interdisciplinarity

    An ugly word for a beautiful idea. Our interdisciplinary approach goes deeper than our science. We believe that the best ideas and the most interesting conversations come from synthesising diverse expertise and experiences.

  • 4

    Dignity and Nurture

    We fundamentally believe in the value of each individual and the worth of their contribution, regardless of the outcome. We thrive best in a nurturing environment, and everything we do is committed to building a supportive culture.

  • 5

    Go where there's a need

    We have the potential to transform lives. We will not let ourselves be sidetracked in this calling. We will not fail those whose future we can save.

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13
Targets screened
to date
50
Phage display programs completed
4
Active target
programs
100
Target programs by end of 2024
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Contact Us

If you are interested in learning more about our drug discovery service, please get in touch with us using the form below.

For partnership inquiries, please email partnerships@antiverse.io.

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About Antiverse

Co-founded in 2017, our team is dedicated to engineering the future of drug discovery to change the course of people’s lives. We are passionate about what we do and the impact our discoveries have on patients across the globe.

Based in Cardiff, our expert team spans structural biology, machine learning and medicine - and together, we are striving for that next breakthrough in drug discovery.

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